MOTS-c

The mitochondrial-derived peptide

Listed strength: 40 mg
Mol. weight: 2173 g/mol
Residues: 16
Class: Mitochondrial-derived peptide (MDP)

40 mg lyophilized vial$3.50/mg · research use only

Reference specifications publishedResearch use only

Research use only · no human or veterinary use, consumption, administration, diagnosis, treatment, prevention, cosmetic use, or food use. Sold to qualified laboratory and analytical users.

01 / What it is

MOTS-c is a 16-residue mitochondrial-derived peptide — encoded within mitochondrial DNA itself. It is studied as a signal linking mitochondrial function to whole-body metabolism, sometimes called an 'exercise-mimetic' in the literature.

02 / Mechanism in the literature

Under metabolic stress, MOTS-c translocates to the nucleus and influences genes tied to metabolic homeostasis and AMPK signaling, connecting mitochondrial status to energy metabolism in research models.

03 / Research context

It appears in exercise-physiology, metabolic, and longevity research as a mitochondrial signaling peptide.

Listed format40 mg lyophilized vial

SequenceMet-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Molecular formulaC101H150N28O22S2

Molecular weight2173 g/mol

Catalogue referenceAGX-10

Listed price$140

PathwayAMPK / metabolic

04 / Common questions

What makes MOTS-c unusual?

It is encoded by mitochondrial DNA rather than the nuclear genome — a relatively recent class of signaling peptides.

Why 'exercise mimetic'?

Research describes MOTS-c activating some of the same metabolic pathways engaged by physical activity.