01 / What it is
Ipamorelin is a synthetic pentapeptide growth-hormone secretagogue and a ghrelin-receptor agonist. It is characterized in the literature as one of the most selective compounds in its class.

Endocrine & growth-factor research · AGX-07
The selective pentapeptide secretagogue
01 / What it is
Ipamorelin is a synthetic pentapeptide growth-hormone secretagogue and a ghrelin-receptor agonist. It is characterized in the literature as one of the most selective compounds in its class.
02 / Mechanism in the literature
It binds the growth-hormone secretagogue receptor (GHS-R1a) to prompt pituitary GH release. Research describes its selectivity as its defining trait: unlike earlier GHRPs, it shows minimal effect on cortisol and prolactin signaling in study models.
03 / Research context
Ipamorelin appears in endocrine and GH-axis literature, often as a selective comparator against earlier growth-hormone-releasing peptides.
04 / Common questions
They act on different receptors — tesamorelin on the GHRH receptor, ipamorelin on the ghrelin/GHS receptor — which is why the literature often studies the two pathways separately.
Earlier growth-hormone-releasing peptides also moved cortisol and prolactin in research models; ipamorelin is characterized as largely sparing those pathways.