01 / What it is
HGH (somatropin) is recombinant human growth hormone — a 191-amino-acid polypeptide identical in sequence to the pituitary hormone. It is the reference molecule for the entire GH-axis research field.

Endocrine & growth-factor research · AGX-14
The 191-amino-acid somatropin reference
01 / What it is
HGH (somatropin) is recombinant human growth hormone — a 191-amino-acid polypeptide identical in sequence to the pituitary hormone. It is the reference molecule for the entire GH-axis research field.
02 / Mechanism in the literature
It binds the growth-hormone receptor to trigger JAK2/STAT5 signaling and downstream hepatic IGF-1 production. Most of the growth-related effects studied in the literature are mediated through that IGF-1 arm.
03 / Research context
Somatropin is the comparator against which secretagogues such as tesamorelin and ipamorelin are evaluated in endocrine research.
04 / Common questions
Recombinant growth hormone is conventionally specified by activity units. 36 IU corresponds to roughly 12 mg at the standard 3 IU/mg conversion.
Somatropin is the hormone itself; secretagogues such as tesamorelin and ipamorelin prompt the pituitary to release its own.