01 / What it is
GHK-Cu is a naturally occurring copper-binding tripeptide (glycyl-histidyl-lysine complexed with copper). It is one of the most-studied compounds in skin-regeneration and matrix-remodeling research.

Dermal, matrix & melanocortin research · AGX-04
The copper-binding matrix tripeptide
01 / What it is
GHK-Cu is a naturally occurring copper-binding tripeptide (glycyl-histidyl-lysine complexed with copper). It is one of the most-studied compounds in skin-regeneration and matrix-remodeling research.
02 / Mechanism in the literature
The GHK sequence binds copper ions and, in research models, influences collagen and glycosaminoglycan synthesis, wound-remodeling signaling, and antioxidant pathways. The copper complex is essential to its activity.
03 / Research context
GHK-Cu appears extensively in dermal, hair-follicle, and tissue-remodeling literature as a regenerative copper peptide.
04 / Common questions
The GHK peptide's activity in research depends on its copper complex — the 'Cu' is part of the active molecule, not incidental.
Same molecule and specification; only the listed fill mass differs.